Negative pregnancy and Rh

Negative pregnancy and Rh


- Can I have a baby if I have negative rh?


Rh negative is the absence of antibodies against factor D on the erythrocyte membrane (red blood cells). In the case of a pregnancy, the Rh of the father depends a lot, and if the father has Rh positive, the Rh of the fetus depends a lot. The product of conception may have Rh positive or negative. If the mother has Rh negative and the fetus is Rh positive, during the birth (or during an abortion) there is a blood transfusion from the fetus to the mother; this blood contains erythrocytes that have factor D on their surface, and the mother's body lacking this factor D, will consider it foreign and will produce anti-factor D antibodies, antibodies that will remain low in the maternal blood and whose concentration will increase. dramatically at a new meeting with erythrocytes having the factor D membrane (this can be prevented by immediate post-partum or post-abortion administration of specific immunoglobulins; the presence of these exogenous immunoglobulins - outside the body - makes the immune system its own the belief that in this way the protection against the aggression of a "non-self" was achieved and therefore no longer produces anti-factor D antibodies).
These antibodies, at a future pregnancy in which the fetus is still Rh positive, can cross the placenta and attack the fetus's blood, leading to fetal distress. Therefore, a good pregnancy monitoring should also include the dosage of anti-D antibodies.
It is possible that the father and / or the fetus will also be Rh negative (then these problems do not exist), and even if the fetus is Rh positive, the antibody titer is likely to remain at values ‚Äč‚Äčthat do not jeopardize the good performance of the pregnancy; but this is very difficult to say without careful monitoring of this task. A good collaboration between you and the obstetrician doctor can result in a pregnancy without problems. Good health!
Dr. Ciprian Pop-Began
- Obstetrics and Gynecology -
Clinical Hospital of Obstetrics-Gynecology Prof. Dr. Panait Sarbu